Exuberant Ca2+ signaling in neutrophils: A cause for concern

Authors
Sayeed, MM
Citation
Mm. Sayeed, Exuberant Ca2+ signaling in neutrophils: A cause for concern, NEWS PHYSL, 15, 2000, pp. 130-136
Citations number
15
Categorie Soggetti
Physiology
Journal title
NEWS IN PHYSIOLOGICAL SCIENCES
ISSN journal
08861714 → ACNP
Volume
15
Year of publication
2000
Pages
130 - 136
Database
ISI
SICI code
0886-1714(200006)15:<130:ECSINA>2.0.ZU;2-S
Abstract
Under inflammatory conditions after burn/trauma injuries, circulating neutr ophils are frequently hyperactive, contributing to excessive superoxide pro duction and related tissue damage. Although normal neutrophil activation is cooperatively controlled by Ca2+-independent and Ca2+-linked signaling pat hways, exuberant Ca2+-linked signaling appears to cause neutrophil hyperact ivation in the injury conditions.