A concise synthesis of topsentin A and nortopsentins B and D

Authors
Miyake, FY Yakushijin, K Horne, DA
Citation
Fy. Miyake et al., A concise synthesis of topsentin A and nortopsentins B and D, ORG LETT, 2(14), 2000, pp. 2121-2123
Citations number
21
Categorie Soggetti
Organic Chemistry/Polymer Science
Journal title
ORGANIC LETTERS
ISSN journal
15237060 → ACNP
Volume
2
Issue
14
Year of publication
2000
Pages
2121 - 2123
Database
ISI
SICI code
1523-7060(20000713)2:14<2121:ACSOTA>2.0.ZU;2-4
Abstract
[GRAPHICS] A concise synthesis of topsentin A (R-1 = R-2 = H) and nortopsentins B (R-1 = Br, R2 = H) and D (R-1 = R-2 = H) is described from oxotryptamine 5 via reduction of acyl cyanide 4, Regiospecific bromination of a cyanoindole aff orded 6-bromo-3-cyanoindole (10) as the major product.