Two-fragment alpha-adrenolytics 3. Addition of primary amines to alkyl divinylphosphinates and phenyl(divinyl)phosphine oxide

Authors
Reznik, VS Levin, YA Akamsin, VD Galyametdinova, IV Pyrkin, RI
Citation
Vs. Reznik et al., Two-fragment alpha-adrenolytics 3. Addition of primary amines to alkyl divinylphosphinates and phenyl(divinyl)phosphine oxide, RUSS CHEM B, 49(3), 2000, pp. 495-498
Citations number
11
Categorie Soggetti
Chemistry
Journal title
RUSSIAN CHEMICAL BULLETIN
ISSN journal
10665285 → ACNP
Volume
49
Issue
3
Year of publication
2000
Pages
495 - 498
Database
ISI
SICI code
1066-5285(200003)49:3<495:TA3AOP>2.0.ZU;2-S
Abstract
Primary alkylamines, beta-aryloxyethylamines, or N-[beta-(2-methoxyphenoxy) ethyl]-alpha,omega-diaminoalkanes react with alkyl divinylphosphinates or p henyl(divinyl)phosphine oxide to give the corresponding 4-alkoxy(4-phenyl)- 1-alkyl-4-oxo-1,4-azaphosphorinanes. Reactions of the latter with mono- or dihaloalkanes afford 4-phosphapiperidinium halides. 1,4-Azaphosphorinanes c ontaining a beta-aryloxyethyl fragment exhibit hypotensive activity.