Neoplasms and their simulators in the bones of the hands and feet incl
ude the majority of those found in other skeletal sites, and a disprop
ortionate number of some. We examined the clinical, radiologic, and pa
thologic features of 240 lesions of the hand and foot bones. Benign tu
mors and lesions including reactive and reparative conditions comprise
d 203 cases. The largest single category of neoplasms was that with ca
rtilaginous differentiation, with enchondromas (29 cases) and chondros
arcomas (15 cases) the most common. Noncartilaginous malignant tumors
were infrequent and displayed typical radiologic and pathologic featur
es. Florid reactive periostitis, bizarre parosteal osteochondromatous
proliferations, and giant cell reparative granulomas made up a larger
percentage of lesions in these locations than in other skeletal sites.
Lesions of the bones of the hands and feet may frequently be biopsied
or treated at hospitals without large orthopedic tumor services. Thus
, it is important for the surgical pathologist to be aware of the freq
uency and characteristics of lesions which may present in these sites.