CLINICAL-STUDY OF TOTALLY ROLLER PUMPLESS CARDIOPULMONARY BYPASS SYSTEM

We have developed a low negative pressure vacuum suction system in whi ch cardiotomy suction is performed by the negative pressure of the ven ous reservoir controlled by a vacuum controller. We have employed this vacuum suction system with a centrifugal pump as a totally roller pum pless cardiopulmonary bypass (CPB) system. In this study, the clinical availability and hemocompatibility of our totally roller pumpless CPB system were evaluated by a randomized prospective study. Thirty patie nts undergoing aortocoronary bypass grafting were assigned to the stud y. Data from seventeen patients treated with a totally roller pumpless CPB system were compared with data from 13 treated with a conventiona l roller pump CPB system. Totally roller pumpless CPB reduces hemolysi s, showing lower plasma free hemoglobin levels (81.8 +/- 25.0 versus 4 2.0 +/- 16.3 at 30 min after CPB initiation, p < 0.05), higher plasma haptoglobin levels (37.8 +/- 36.6 versus 77.2 +/- 31.3 at 120 min afte r CPB, p < 0.05), and lower blood lactate dehydrogenase (LDH) levels ( 1391 +/- 497 versus 972 +/- 187, p < 0.01) than those of CPB with a ro ller pump suction with no significant difference between platelet coun ts. Arterial blood oxygen tension after using a totally roller pumples s CPB system was slightly better than that with a roller pump (396 +/- 48 versus 437 +/- 43, p = 0.069); however, there was no significant d ifference in intubation times between groups. A totally roller pumples s CPB system provides sufficient biocompatibility for the blood to red uce hemolysis significantly and simplifies and miniaturizes the entire CPB system to achieve good visuality and handling for control as well .