PREVENTION OF REMOTE ORGAN INJURY IN CARDIOPULMONARY BYPASS - THE IMPACT OF FLOW GENERATION TECHNIQUE

The purpose of this study was to investigate the effects of 3 differen t types of flow generation for cardiopulmonary bypass on gastrointesti nal permeability and on neutrophil expression of CDllb, a surface mark er of neutrophil activation. Fourteen patients undergoing elective cor onary revascularization were selected randomly to receive 1 of the 3 f low generation techniques (roller, pulsatile, or centrifugal). Intesti nal permeability was assessed by the fraction of an oral dose of (51)c hromium-ethylenediaminetetraacetate (Cr-51-EDTA) recovered in the urin e over 24 h. Neutrophil activation was determined by expression of CDl lb markers at 6 time points. Overall, the 14 patients showed significa nt increases in intestinal permeability. It was not possible to demons trate statistically significant differences among the now generation g roups; however, when compared to both roller pump groups, the centrifu gal pump group showed a 3.2% reduction in intestinal permeability. The re was no change in the expression of CDllb receptors throughout the t ime points, nor was there a relationship of CDllb markers to the flow generation technique.