Iris involvement in primary intraocular lymphoma: Report of two cases and review of the literature

Non-Hodgkin's lymphoma involves ocular tissues either as a primary tumor or as secondary metastasis from systemic disease. Diagnosis is based on the i dentification of malignant cells in the eye by biopsy. Although primary int raocular lymphoma cells have been identified in the optic nerve, ciliary bo dy, and iris of a small number of patients by histopathology, these sites o f infiltration have rarely been observed on clinical examination. We studie d clinical and histopathological findings of two patients with iris infiltr ation by primary intraocular lymphoma and reviewed the findings of 163 case s reported in the literature. (Surv Ophthalmol 44:518-526, 2000. (C) 2000 b y Elsevier Science Inc. All rights reserved.).