New chiral sulfoxide ligands possessing a phosphano or phosphanoamino functionality in palladium-catalyzed asymmetric allylic nucleophilic substitution reactions

New chiral sulfoxide ligands possessing a phosphano or phosphanoamino funct ionality as an alternative coordinating element were developed, and their u sefulness was demonstrated by applying them to palladium-catalyzed asymmetr ic allylic nucleophilic substitution reactions. The structure of the cataly st precursor coordinated by the chiral phosphino sulfoxide was determined b y X-ray crystallographic analysis. The possible mechanism for the asymmetri c induction using these chiral ligands was proposed on the basis of the ste reochemical outcome obtained. (C) 2000 Elsevier Science Ltd. All rights res erved.