Mt. Barros et F. Sineriz, Total synthesis of saturated and unsaturated di-trans-N-substituted cyclam-based macrocycles through a versatile intermediate, TETRAHEDRON, 56(27), 2000, pp. 4759-4764
A total synthesis of di-trans-N-substituted cyclam-type macrocycles through
a versatile intermediate is described for the first time. This synthesis u
ses readily available low-cost commercial reagents. This synthesis was desi
gned in such a way that the products and some intermediates could be select
ively deprotected providing versatility both during the synthesis and for t
he utility of the final product. Thus, it should be possible to form crypta
nd molecules with trans bridges with good selectivity. (C) 2000 Elsevier Sc
ience Ltd. All rights reserved.