Total synthesis of saturated and unsaturated di-trans-N-substituted cyclam-based macrocycles through a versatile intermediate

A total synthesis of di-trans-N-substituted cyclam-type macrocycles through a versatile intermediate is described for the first time. This synthesis u ses readily available low-cost commercial reagents. This synthesis was desi gned in such a way that the products and some intermediates could be select ively deprotected providing versatility both during the synthesis and for t he utility of the final product. Thus, it should be possible to form crypta nd molecules with trans bridges with good selectivity. (C) 2000 Elsevier Sc ience Ltd. All rights reserved.