C. Perez-martinez et al., Malignant fibrous histiocytoma (giant cell type) associated with a malignant mixed tumor in the salivary gland of a dog, VET PATH, 37(4), 2000, pp. 350-353
Citations number
13
Categorie Soggetti
Veterinary Medicine/Animal Health","Medical Research Diagnosis & Treatment
A 12-year-old male Boxer dog presented with a 5 X 5 X 7-cm partially encaps
ulated mass in the right mandibular salivary gland. Histologically, the mas
s was composed of neoplastic epithelial and mesenchymal cells. The mesenchy
mal component consisted of two cell populations arranged in different patte
rns: coalescing nodules of neoplastic mononuclear cells with rare osteoid a
nd numerous osteoclastlike giant cells; and sheets of neoplastic spindle ce
lls intermingled with neoplastic epithelial cells and containing osteoid an
d well-formed bone trabeculae lined by osteoblasts and few osteoclastlike g
iant cells. On the basis of these histological features, two malignant sali
vary tumors were diagnosed: a malignant fibrous histiocytoma (giant cell ty
pe! and a malignant mixed tumor. Immunohistochemical studies demonstrated k
eratin 5 and 8 expression by the neoplastic epithelial cells, indicating a
probable salivary ductal origin, and vimentin expression by all mesenchymal
elements, suggesting a fibroblastic line of differentiation.