A case of membranoproliferative glomerulonephritis associated with a hydatidiform mole

We treated a 54-year-old woman who was suffering from membranoproliferative glomerulonephritis associated with a complete type of hydatidiform mole. T he renal manifestations were proteinuria and hematuria. A renal biopsy, per formed before gynecologic management, disclosed focal and segmental subendo thelial deposits with a proliferation of the mesangial cell and showed irre gularly thickened capillary loops by light and electronmicroscoy. Genralize d edema, proteinuria and hematuria were completely recovered by suction and curettage of the hydatidiform mole with prophylactic chemotherapy. The cli nical manifestation of earlier presented 3 cases have been the nephrotic sy ndrome. The common feature of them was a complete remission of the nephropa thy after the removal of the hydatidiform mole. The relationship between th e hydatidiform mole and glomerulonephritis remains unresolved at present. B ut we concluded that the hydatidiform mole might be a cause of glomerulonep hritis in this case.