NMDA receptor mechanism involved in arterial baroreflex

Citation
Jj. Wang et al., NMDA receptor mechanism involved in arterial baroreflex, ACT PHAR SI, 21(7), 2000, pp. 617-622
Citations number
14
Categorie Soggetti
Pharmacology & Toxicology
Journal title
ACTA PHARMACOLOGICA SINICA
ISSN journal
02539756 → ACNP
Volume
21
Issue
7
Year of publication
2000
Pages
617 - 622
Database
ISI
SICI code
0253-9756(200007)21:7<617:NRMIIA>2.0.ZU;2-5
Abstract
AIM: To study the roles of N-methyl-D-aspartate (NMDA) receptors in arteria l baroreflex. METHODS: Experiments were performed in 17 urethane-anaestheti zed male Sprague-Dawly rats. Twenty-seven rostral ventrolateral medulla (RV LM) neurons were electrophysiologically identified as putative presympathet ic neurons. Responses of these neurons to baroreflex activation were used a s an index to observe the effects of 3-(2-carboxypiperazin-4-yl) propyl-l-p hosphonic acid (CPP) microinjected (0.1 mu L, 50 mmol . L-1) into the nucle us tractus solitarii (NTS) or the caudal ventrolateral medulla (NLM) ipsila terally. RESULTS: In the NTS, CPP eliminated or attenuated the inhibition o f these neurons induced by aortic nerve stimulation, but the inhibition ind uced by elevation of arterial pressure was not eliminated and the cardiac c ycle-related rhythm of spontaneous discharge still existed. Whereas in the CVLM, CPP eliminated not only the inhibition of these neurons induced by ao rtic nerve stimulation, but the inhibition induced by blood pressure elevat ion and the cardiac cycle-related rhythm of spontaneous discharge disappear ed. CONCLUSION: NMDA mechanism is importantly involved in the mechanism of baroreflex both in the NTS and in the CVLM; the barosensitive neurons in th e NTS project to ipsilateral CVLM.