E. Staunton et al., Triggering of transient LES relaxations in ferrets: role of sympathetic pathways and effects of baclofen, AM J P-GAST, 279(1), 2000, pp. G157-G162
Citations number
20
Categorie Soggetti
da verificare
Journal title
AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY
Activation of gastric vagal mechanoreceptors by distention is thought to be
the trigger for transient lower esophageal sphincter relaxations (TLESR),
which lead to gastroesophageal reflux. The contribution of higher-threshold
gastric splanchnic mechanoreceptors is uninvestigated. GABA(B) receptor ag
onists, including baclofen, potently reduce triggering of TLESR by low-leve
l gastric distention. We aimed to determine first whether this effect of ba
clofen is maintained at high-level distention and second the role of splanc
hnic pathways in triggering TLESR. Micromanometric/pH studies in conscious
ferrets showed that intragastric glucose infusion (25 ml) increased trigger
ing of TLESR and reflux. Both were significantly reduced by baclofen (7 mu
mol/kg ip) (P< 0.05). When 40 ml of air was added to the glucose infusion,
more TLESR occurred than with glucose alone (P< 0.01). These were also redu
ced by baclofen (P< 0.001). TLESR after glucose/air infusion were assessed
before and after splanchnectomy (2-4, 9-11, and 23-25 days), which revealed
no change. Baclofen inhibits TLESR after both low- and high-level gastric
distention. Splanchnic pathways do not contribute to increased triggering o
f TLESR by high-level gastric distention.