Factor analysis of changes in dyspnea and lung function parameters after bronchodilation in chronic obstructive pulmonary disease

Expiratory airway collapse is a characteristic feature in patients with chr onic obstructive pulmonary disease (COPD). We hypothesized that this collap se might mask the effects of bronchodilators during forced expiration but n ot during forced inspiration, and that accordingly, the improvement in forc ed inspiration and not that in forced expiration with bronchodilator therap y would be related to changes in the perception of dyspnea. In order to inv estigate this, we conducted lung function measurements, including measureme nts of forced inspiration and expiration before and 30 min after inhalation of 400 mu g salbutamol, in 61 patients with COPD (mean FEV1: 38.3 L; range : 12.9 to 795% predicted). The change in dyspnea from baseline was assessed with a standard visual analogue scale (VAS) ranging from -100 to +100. To delineate the relationship between parameters, we used the statistical proc edure of factor analysis. Salbutamol induced an improvement of 0.16 +/- 0.0 2 L (mean +/- SD) in FEV1, 0.36 +/- 0.04 L in forced inspiratory volume in one second (FIV1), 0.30 +/- 0.04 L in inspiratory capacity (IC), and -0.34 +/- 0.07 L in intrathoracic gas volume; the mean VAS score was 36.4 +/- 3.2 . Factor analysis demonstrated that the reduction in dyspnea at rest was pr imarily associated with changes in parameters describing forced inspiration and not with those of forced expiration or lung hyperinflation, including IC. Our data indicate that in patients with COPD, the reduction in dyspnea after inhalation of a beta(2)-adrenoreceptor agonist is closely correlated with the change in parameters of forced inspiration, and particularly FIV1, but not with changes in parameters of forced expiration or lung hyperinfla tion.