P. Armingaud et al., Localized bullous eruption after intravenous injection of aciclovir: toxicor immunoallergic mechanism?, ANN DER VEN, 127(5), 2000, pp. 496-498
Objective. To report a case of bullous eruption at and far from the site of
aciclovir injection.
Case report. A 50-year old man was treated with intravenous aciclovir for H
erpes simplex meningoencephalitis. Ten days after treatment onset, blisters
appeared on his right forearm, at and far from the site of aciclovir injec
tion.
Discussion. This adverse effect has not been frequently reported. To date,
bullous eruptions were considered to result from extravasation of the acicl
ovir solution. In this case, an immunoallergic pattern was discussed with t
he presence of a histological leukocytoclastic vasculitis.