Localized bullous eruption after intravenous injection of aciclovir: toxicor immunoallergic mechanism?

Objective. To report a case of bullous eruption at and far from the site of aciclovir injection. Case report. A 50-year old man was treated with intravenous aciclovir for H erpes simplex meningoencephalitis. Ten days after treatment onset, blisters appeared on his right forearm, at and far from the site of aciclovir injec tion. Discussion. This adverse effect has not been frequently reported. To date, bullous eruptions were considered to result from extravasation of the acicl ovir solution. In this case, an immunoallergic pattern was discussed with t he presence of a histological leukocytoclastic vasculitis.