Structure-activity relationships for selected sulfur-rich antithrombotic compounds

We assessed the antithrombotic activity of some simple organosulfur compoun ds which have some of the functionality found in the disulfide ajoene, a ph armacologically active compound isolated from garlic. The results establish that antithrombotic activity is associated with disulfides directly attach ed to a phenyl ring and is further enhanced by an alpha-sulfonyl group. CH3 SO2CH2SSPh proved to be a potent inhibitor of platelet aggregation with an IC50 of 5 mu M. (C) 2000 Academic Press.