Reciprocal expression of infant- and adult-preferring transcripts of CDCrel-1 septin gene in the rat neocortex

We report here the isolation and characterization of cDNA clones for a nove l isoform of CDCrel-1 septin, termed CDCrel-1A, with a different 5' end seq uence from the transcripts encoding the known CDCrel-1 (designated as CDCre l-1F) in the developing rat neocortex, Alternative polyadenylation site sel ections resulted in various transcripts for CDCrel-1A including the fusion forms with another gene, platelet glycoprotein Ib beta (GPIb beta). Express ion of the distinct transcripts encoding CDCrel-1A and CDCrel-1F increased and decreased, respectively, from the infant to adult period, Therefore CDC rel-1A might be a major form of the CDCrel-1 septin in the adult neocortex of mammals. (C) 2000 Academic Press.