1-aminomethylisoquinoline-4-carboxylates as novel dipeptidylpeptidase IV inhibitors

Authors
Coppola, GM Zhang, YL Schuster, HF Russell, ME Hughes, TE
Citation
Gm. Coppola et al., 1-aminomethylisoquinoline-4-carboxylates as novel dipeptidylpeptidase IV inhibitors, BIOORG MED, 10(14), 2000, pp. 1555-1558
Citations number
14
Categorie Soggetti
Chemistry & Analysis
Journal title
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
ISSN journal
0960894X → ACNP
Volume
10
Issue
14
Year of publication
2000
Pages
1555 - 1558
Database
ISI
SICI code
0960-894X(20000717)10:14<1555:1ANDII>2.0.ZU;2-V
Abstract
Structure-activity relationship within a series of 1-aminoalkylisoquinoline -4-carboxylates as inhibitors of DPP-IV is described. A primary aminomethyl group is required to maintain biological activity. Substitution of the iso quinoline at the 6- and 8-positions with methoxy groups increases potency t o 53 times that of the lead compound SDZ 029-576. (C) 2000 Elsevier Science Ltd. All rights reserved.