Kinetic characterisation of ene-diol-based inhibitors of alpha-amylase

Authors
Gerrand, JA Prince, MJ Abell, AD
Citation
Ja. Gerrand et al., Kinetic characterisation of ene-diol-based inhibitors of alpha-amylase, BIOORG MED, 10(14), 2000, pp. 1575-1576
Citations number
12
Categorie Soggetti
Chemistry & Analysis
Journal title
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
ISSN journal
0960894X → ACNP
Volume
10
Issue
14
Year of publication
2000
Pages
1575 - 1576
Database
ISI
SICI code
0960-894X(20000717)10:14<1575:KCOEIO>2.0.ZU;2-F
Abstract
A kinetic analysis of the inhibition of malt alpha-amylase by compounds bas ed on ascorbic acid has shown the mode of inhibition to be competitive for the parent compound, but more complex for its derivatives. We have further simplified the ascorbic acid ene-diol pharmacophore by demonstrating that d ihydroxyfumaric acid is also a good inhibitor of malt alpha-amylase. (C) 20 00 Elsevier Science Ltd. All rights reserved.