Citation
Jy. Ma et al., Acid catalyzed Michael additions to artemisitene, BIOORG MED, 10(14), 2000, pp. 1601-1603
Citations number
13
Categorie Soggetti
Chemistry & Analysis
Journal title
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
ISSN journal
0960894X
→ ACNP
Volume
10
Issue
14
Year of publication
2000
Pages
1601 - 1603
Database
ISI
SICI code
0960-894X(20000717)10:14<1601:ACMATA>2.0.ZU;2-K
Abstract
A series of 14-substituted-artemisinin and 9-epiartemisinin derivatives was
prepared by a titanium-tetrachloride catalyzed addition of trimethylsilyl
enol ethers to artemisitene. Several compounds were four to seven times mor
e active than artemisinin against Plasmodium falciparum. (C) 2000 Published
by Elsevier Science Ltd. All rights reserved.