Advances in enzymatic transformation of penicillins to 6-aminopenicillanicacid (6-APA)

Authors
Parmar, A Kumar, H Marwaha, S Kennedy, JF
Citation
A. Parmar et al., Advances in enzymatic transformation of penicillins to 6-aminopenicillanicacid (6-APA), BIOTECH ADV, 18(4), 2000, pp. 289-301
Citations number
81
Categorie Soggetti
Biotecnology & Applied Microbiology
Journal title
BIOTECHNOLOGY ADVANCES
ISSN journal
07349750 → ACNP
Volume
18
Issue
4
Year of publication
2000
Pages
289 - 301
Database
ISI
SICI code
0734-9750(200007)18:4<289:AIETOP>2.0.ZU;2-D
Abstract
This article elaborates on the important recent developments in the enzymat ic transformation of penicillins to 6-aminopenicillanic acid (B-APA), which is the basic raw material for the industrial production of semisynthetic p enicillins such as amoxycillin and ampicillin. Particular emphasis is place d on the improvements in purification, stability, and immobilization of the enzymes, (i.e. penicillin acylases) used for these transformations. (C) 20 00 Elsevier Science Inc. All rights reserved.