Paired filtration dialysis is a modified form of hemodiafiltration with a d
ouble-chamber hollow fiber. Convection is separated from diffusion, elimina
ting the potential risk of backfiltration (which can contain endotoxin or c
ytokine-inducing substances). The regeneration of high volumes of plasma ul
trafiltrate obtained in the first filter allows a large plasma volume to be
treated, and at the same time enables the return of many beneficial substa
nces such as hormones, small peptides and many vitamins. Ultrafiltrate is r
egenerated with a charcoal-resin device and reinfused to the patient. Hemod
iafiltration with on-line endogenous reinfusion is an easy and safe procedu
re. In addition, the method avoids risks associated with exogenous fluid in
fusion (endotoxin, pyrogens), allows exchange at no extra costs of large vo
lumes of fluids and reduction in storage of fluid bags. Clinical advantages
also include infusion of physiological fluid containing bicarbonate and ca
lcium, good clinical tolerance and cardiovascular stability. Copyright (C)
2000 S. Karger AG, Basel.