Hemodiafiltration with on-line endogenous reinfusion

Paired filtration dialysis is a modified form of hemodiafiltration with a d ouble-chamber hollow fiber. Convection is separated from diffusion, elimina ting the potential risk of backfiltration (which can contain endotoxin or c ytokine-inducing substances). The regeneration of high volumes of plasma ul trafiltrate obtained in the first filter allows a large plasma volume to be treated, and at the same time enables the return of many beneficial substa nces such as hormones, small peptides and many vitamins. Ultrafiltrate is r egenerated with a charcoal-resin device and reinfused to the patient. Hemod iafiltration with on-line endogenous reinfusion is an easy and safe procedu re. In addition, the method avoids risks associated with exogenous fluid in fusion (endotoxin, pyrogens), allows exchange at no extra costs of large vo lumes of fluids and reduction in storage of fluid bags. Clinical advantages also include infusion of physiological fluid containing bicarbonate and ca lcium, good clinical tolerance and cardiovascular stability. Copyright (C) 2000 S. Karger AG, Basel.