Immunotherapy of hematologic malignancies and metastatic solid tumors in experimental animals and man

Authors
Slavin, S Or, R Prighozina, T Gurevitch, O Aker, M Panighari, S Shapira, M Nagler, A
Citation
S. Slavin et al., Immunotherapy of hematologic malignancies and metastatic solid tumors in experimental animals and man, BONE MAR TR, 25, 2000, pp. S54-S57
Citations number
23
Categorie Soggetti
Hematology,"Medical Research Diagnosis & Treatment
Journal title
BONE MARROW TRANSPLANTATION
ISSN journal
02683369 → ACNP
Volume
25
Year of publication
2000
Supplement
2
Pages
S54 - S57
Database
ISI
SICI code
0268-3369(200005)25:<S54:IOHMAM>2.0.ZU;2-1
Abstract
Following engraftment of donor hematopoietic cells and induction of host-ve rsus-graft tolerance, immunocompetent lymphocytes of donor origin can induc e graft-versus-leukemia (GVL) and graft-versus-tumor (GVT) effects. Engraft ment of allogeneic bone marrow cells can be accomplished following non-myel oablative conditioning while possibly controlling graft-versus-host disease (GVHD). GVL and GVT effects may thus be successfully accomplished followin g non-myeloablative stem cell transplantation (NST) as shown by data derive d from experimental animals and man.