Bone marrow transplantation does not correct the hyper IgE syndrome

Congenital immunodeficiency in hyper IgE syndrome is characterised by a mar kedly raised IgE level, recurrent staphylococcal skin infection and pneumat oceles. Standard treatments include anti-staphylococcal antibiotics. We rep ort a severely affected patient in whom successful bone marrow transplantat ion was followed by reappearance of the immunodeficiency. We conclude that bone marrow transplantation does not cure the immunological features of the hyper IgE syndrome.