We describe two men with multiple erythematous dermal nodules which were cl
inically and histologically consistent with a diagnosis of primary cutaneou
s immunocytoma. Both patients exhibited the very unusual feature of seconda
ry anetoderma occurring in spontaneously resolving lesions. There is one pr
evious report of anetoderma in association with a plasmacytoma. The pathoge
nesis remains unknown but release of cytokines such as interleukin-6 may be
implicated.