Trabeculectomy with mitomycin C for post-keratoplasty glaucoma

Aim-To investigate the effect of trabeculectomy with and without mitomycin C in post-keratoplasty glaucoma. Methods-A retrospective study was performed on patients who underwent trabe culectomy for glaucoma after penetrating keratoplasty. 34 eyes of 32 patien ts were included in this study. 26 eyes received trabeculectomy with mitomy cin C and eight eyes without mitomycin C. The procedure was deemed successf ul if the intraocular pressure was maintained below 21 mm Hg with or withou t use of additional antiglaucoma medication (mean follow up time 22.3 (SD 1 0.3) months). Results-At the last examination trabeculectomy was successful in 19 of 26 e yes (73.0%) with mitomycin C (+) and two of eight (25.0%) without (p=0.0219 ). When the prognosis was analysed by Kaplan-Meier curve, the mitomycin C ( +) group showed a better prognosis (p=0.0182). Mean intraocular pressure an d average number of glaucoma medications improved in the group with mitomyc in C without severe side effects on the graft. Graft rejection after trabec ulectomy was seen in two eyes in the mitomycin C group. Final graft clarity rate was 69.2% (18/26) in the mitomycin C (+) group and 37.5% (3/8) in the mitomycin C (-) group. Complications such as persistent epithelial defect, cystoid macular oedema, choroidal detachment, leakage from bleb were seen in four eyes in the mitomycin C (+) group and in one eye in the mitomycin C (-) group. Conclusions-Trabeculectomy with mitomycin C showed better results for glauc oma following keratoplasty.