Synthesis of diaryl-substituted imidazo[1,2-a]pyridines designed as potential aromatase inhibitors

Authors
Enguehard, C Renou, JL Allouchi, H Leger, JM Gueiffier, A
Citation
C. Enguehard et al., Synthesis of diaryl-substituted imidazo[1,2-a]pyridines designed as potential aromatase inhibitors, CHEM PHARM, 48(7), 2000, pp. 935-940
Citations number
26
Categorie Soggetti
Chemistry & Analysis
Journal title
CHEMICAL & PHARMACEUTICAL BULLETIN
ISSN journal
00092363 → ACNP
Volume
48
Issue
7
Year of publication
2000
Pages
935 - 940
Database
ISI
SICI code
0009-2363(200007)48:7<935:SODIDA>2.0.ZU;2-L
Abstract
From a pharmacophore model of bicyclic heterocycles as aromatase inhibitors we have designed three series of imidazo[1,2-a]pyridine derivatives. The s ynthesis and the spectroscopy determination of various compounds are report ed. The crystal data of one of these compounds (10b) was obtained, The arom atase inhibition potency was evaluated in vitro and no activity was found.