A new cytotoxic polyhydroxysterol from soft coral Sarcophyton trocheliophorum

Authors
Dong, H Gou, YL Kini, RM Xu, HX Chen, SX Teo, SLM But, PPH
Citation
H. Dong et al., A new cytotoxic polyhydroxysterol from soft coral Sarcophyton trocheliophorum, CHEM PHARM, 48(7), 2000, pp. 1087-1089
Citations number
18
Categorie Soggetti
Chemistry & Analysis
Journal title
CHEMICAL & PHARMACEUTICAL BULLETIN
ISSN journal
00092363 → ACNP
Volume
48
Issue
7
Year of publication
2000
Pages
1087 - 1089
Database
ISI
SICI code
0009-2363(200007)48:7<1087:ANCPFS>2.0.ZU;2-0
Abstract
A new cytotoxic polyhydroxysterol, 23,24-dimethylcholest-16(17)-E-en-3 beta ,5 alpha,6 beta,20(S)-tetraol (2), together with nine known compounds was i solated from the soft coral Sarcophyton trocheliophorum. Their structures w ere determined by spectroscopic methods. Compound 2 showed potent growth in hibitory activity against human HL60 leukemia, M14 skin melanoma, and MCF7 breast carcinoma cells with EC50 values of 2.8, 4.3, and 4.9 mu g/ml, respe ctively, and exhibited minimal toxicity to normal human peripheral blood ly mphocytes.