In-vitro interaction of liposome encapsulated hemoglobin with blood components

This study involves an in-vitro experimental approach that was designed to investigate the possible interaction between liposome encapsulated hemoglob in (LEH). Reverse micelle processing was used to produce LEH. The study pre sented here does not indicate any negative interaction between LEH formed b y reverse micelle method and relevant blood cells, namely platelets and red blood cells. Liposomes encapsulated hemoglobin affected rheological proper ties of blood, and Newtonian behavior is observed as a result of mixing LEH with whole blood (WHB). Neither shear induced nor stagnant hemolyses were significant. Moreover, platelets do not seem to be activated as a result of mixing WHB with LEH.