Crystallization thermodynamic and kinetic behaviors of vitamin C in batch crystallizer

The bench-scale cooling crystallization for ternary solution of L-ascorbic acid (Vitamin C) was studied.. The solid-liquid phase diagram of Vitamin C- water-ethanol system was obtained on the basis of differential scanning cal orimeter (DSC) curves. The heat of crystallization of Vitamin C was calcula ted with the aid of quantitative analysis. According to the population bala nce equation under unsteady state, the rates of nucleation and growth were determined. The parameters of crystallization kinetics equations were estim ated by regression of experimental data. Crystal morphology and size were d etermined with x-ray diffraction and TA II Coulter Counter.