Gas chromatographic enantiomer separation on single and mixed cyclodextrinderivative chiral stationary phases

Capillary gas chromatographic enantiomer separation of some polar compounds , including alpha-phenylethylamine, styrene oxide, pyrethroid insecticides and other carboxylates, was investigated on modified cyclodextrin (CD) chir al stationary phases. The chiral stationary phases studied included permeth ylated beta-CD (PMBCD), heptakis (2,6-di-O-butyl-3-O-butyryl)-beta-CD (DBBB CD), heptakis (2,6-di-O-nonyl-3-O-trifluoroacetyl)-beta-CD (DNTBCD), the mi xture of PMBCD and DBBBCD, and the mixture of PMBCD and DNTBCD. On the mixe d chiral stationary phases containing the mixtures of derivatized cyclodext rins, enantiomer separation was improved significantly for some compounds a s compared to the single cyclodextrin derivative chiral stationary phases, and synergistic effects were observed for some compounds on the mixed cyclo dextrin derivative chiral stationary phases.