The hybrid modelling approach for bioprocesses combines a neural network re
presentation of the reaction rates with a mass-balance description of the r
eactor. A procedure for the identification of hybrid models is proposed and
illustrated with an experimental case-study. The key feature is a state tr
ansformation which allows to identify separately the kinetic models of the
reaction rates even if they occur simultaneously in the reactor. (C) 2000 E
lsevier Science Ltd. All rights reserved.