Connecting vesicle transport to the cytoskeleton

The cytoskeleton is crucial for the efficient and polarized transport of ve sicles in intracellular membrane-sorting pathways, Recent studies have iden tified specific kinesin, dynein, and myosin motor proteins that mediate def ined membrane transport steps. Important clues have also been uncovered abo ut the nature of motor-protein receptors on vesicular cargoes and the molec ular mechanisms of motor protein regulation.