Genomic localization of the human genes TAF1A, TAF1B and TAF1C, encoding TAF(I)48, TAF(I)63 and TAF(I)110 subunits of class I general transcription initiation factor SL1
C. Di Pietro et al., Genomic localization of the human genes TAF1A, TAF1B and TAF1C, encoding TAF(I)48, TAF(I)63 and TAF(I)110 subunits of class I general transcription initiation factor SL1, CYTOG C GEN, 89(1-2), 2000, pp. 133-136
Human SL1 is a general transcription initiation factor (GTF) essential for
RNA polymerase I to start rRNA synthesis at class I promoters. It is compri
sed of the TATA box-binding protein (TBP) and three TBP-associated factors
(TAF(I)48, TAF(I)63 and TAF(I)110). We have determined that the human genes
TAF1A, TAF1B and TAF1C, encoding these three TAF(I) polypeptides, are loca
lized at 1q42, 2p25 and 16q24, respectively. All three genes are present as
single copies in the human genome and map to different chromosomes, as sho
wn by somatic cell hybrid panel and radiation hybrid panel analysis and FIS
H. Two of these genes, TAF1C and TAF1B, are transcribed into multiple RNAs,
as determined through Northern analysis of mRNA from various human organs
and cell lines. If translated into different polypeptides, this could resul
t in production of variant isoforms of SL1 with different activation potent
ials. Copyright(C)2000S.KargerAG.Basel.