Genomic localization of the human genes TAF1A, TAF1B and TAF1C, encoding TAF(I)48, TAF(I)63 and TAF(I)110 subunits of class I general transcription initiation factor SL1

Citation
C. Di Pietro et al., Genomic localization of the human genes TAF1A, TAF1B and TAF1C, encoding TAF(I)48, TAF(I)63 and TAF(I)110 subunits of class I general transcription initiation factor SL1, CYTOG C GEN, 89(1-2), 2000, pp. 133-136
Citations number
15
Categorie Soggetti
Molecular Biology & Genetics
Journal title
CYTOGENETICS AND CELL GENETICS
ISSN journal
03010171 → ACNP
Volume
89
Issue
1-2
Year of publication
2000
Pages
133 - 136
Database
ISI
SICI code
0301-0171(2000)89:1-2<133:GLOTHG>2.0.ZU;2-N
Abstract
Human SL1 is a general transcription initiation factor (GTF) essential for RNA polymerase I to start rRNA synthesis at class I promoters. It is compri sed of the TATA box-binding protein (TBP) and three TBP-associated factors (TAF(I)48, TAF(I)63 and TAF(I)110). We have determined that the human genes TAF1A, TAF1B and TAF1C, encoding these three TAF(I) polypeptides, are loca lized at 1q42, 2p25 and 16q24, respectively. All three genes are present as single copies in the human genome and map to different chromosomes, as sho wn by somatic cell hybrid panel and radiation hybrid panel analysis and FIS H. Two of these genes, TAF1C and TAF1B, are transcribed into multiple RNAs, as determined through Northern analysis of mRNA from various human organs and cell lines. If translated into different polypeptides, this could resul t in production of variant isoforms of SL1 with different activation potent ials. Copyright(C)2000S.KargerAG.Basel.