Genomic organization of the human ubiquitin-conjugating enzyme gene, UBE2L6 on chromosome 11q12

The human UBE2L6 gene encodes UbcH8(Kumar), a ubiquitin-conjugating enzyme (E2) highly simliar in primary structure to UbcH7 which is encoded by UBE2L 3. Like UBC4 and UBC5 in yeast, these proteins demonstrate functional redun dancy. Herein we report the intron/exon structure of UBE2L6. Comparison of the genomic organization of UBE2L6 with UBE2L3 demonstrates that these gene s remain highly conserved at the genomic as well as at the protein level. W e also describe the chromosomal localization of UBE2L6, which maps to chrom osome 11q12. Copyright(C)2000S.KargerAG,Basel.