Chromosome mapping of RNF16 and Rnf16, human, mouse and rat genes coding for testis RING finger protein (terf), a member of the RING finger family

RNF16 (ring finger protein 16, alias terf), a member of the RING finger fam ily, has been shown to be exclusively expressed in the testis. Human RNF16 is located at 1q42 based on PCR-assisted analysis of both a human/rodent mo no-chromosomal hybrid cell panel and a radiation hybrid-mapping panel. On t he other hand, chromosomal mapping of the RNF16 gene by fluorescence in sit u hybridization reveals that mouse Rnf16 is located at 11B1.2-B1.3 and rat Rnf16 at 10q22. These results provide additional evidence that the mouse 11 B region displays conserved linkage homology with the rat 10q22 region, whe reas in the case of RNF16, this homology is only conserved among rodents, d istinct from the 1q42 region of the human genome. Copyright(C)2000S.KargerA G,Basel.