What's new with tumor markers for colorectal cancer?

Background/Aims: Many tumor markers have been utilized in the follow-up car e of colorectal cancer patients. No marker, however, has proven reliably ac curate in detecting recurrent disease. Methods: The strengths and weaknesse s of currently available tumor markers are reviewed, with attention to rela ted cost and efficacy. Results: Tumor antigens, enzymes, and genetic marker s have been used as tumor markers. CEA and CA 19.9 are the most widely util ized; however, genetic markers are the most promising for the future, Concl usions: Currently available markers have significant limitations, Developme nt of genetic markers may greatly enhance our ability to predict prognosis and the need for adjuvant therapy. Marker-guided therapy may play an increa sing role in this disease. Copyright (C) 2000 S. Karger AG, Basel.