Repair of fistulas-in-ano using fibrin adhesive - Long-term follow-up

Citation
Jr. Cintron et al., Repair of fistulas-in-ano using fibrin adhesive - Long-term follow-up, DIS COL REC, 43(7), 2000, pp. 944-949
Citations number
16
Categorie Soggetti
Gastroenerology and Hepatology
Journal title
DISEASES OF THE COLON & RECTUM
ISSN journal
00123706 → ACNP
Volume
43
Issue
7
Year of publication
2000
Pages
944 - 949
Database
ISI
SICI code
0012-3706(200007)43:7<944:ROFUFA>2.0.ZU;2-D
Abstract
PURPOSE: Fibrin adhesive has been successfully used to treat fistulas-in-an o, but long-term data have been lacking. We report the results of our 18-mo nth study examining the repair of fisrulas-in-ano using autologous and comm ercial fibrin adhesive. METHODS: A 79-patient, prospective, nonrandomized c linical trial was performed in which fibrin adhesive was used to repair fis tulas-in-ano. Twenty-six patients were treated with autologous fibrin tissu e adhesive made from their own blood, and 53 patients were treated with com mercial fibrin sealant. To. the operating room the patient underwent an exa mination under anesthesia, with an attempt to identify the primary and seco ndary fistula tract openings. The fistula tract was then curetted. Fibrin a dhesive was injected into the secondary fistula tract opening until adhesiv e was seen coming from the primary opening. A petroleum jelly gauze was the n applied over both the primary and secondary openings, and the patient was sent home. Follow-up visits occurred one week, one month, three months, an d one year later. RESULTS: Fourteen of 26 (54 percent) patients treated wit h autologous fibrin tissue adhesive made from their own blood had complete closure of their fistulas after a one-year;ir follow-up, whereas 34 of 53 ( 64 percent) patients treated with commercial fibrin sealant had closure of their fistulas. Most treatment failures occurred within the first 3 months, but late failures were seen as far as 11 months postoperative. CONCLUSIONS : Fibrin tissue adhesive offers a unique mode of managing fistulasin-ano, w hich is surgically less invasive, but recurrences up to one year later are being seen. Longer follow-up and further research is recommended for improv ement.