ELECTROSTATIC INTERACTIONS AND ION-TRANSPORT IN NARROW CHANNELS - THEMODEL SYSTEM GRAMICIDIN

Authors
SANCHO M
Citation
M. Sancho, ELECTROSTATIC INTERACTIONS AND ION-TRANSPORT IN NARROW CHANNELS - THEMODEL SYSTEM GRAMICIDIN, Solid state ionics, 97(1-4), 1997, pp. 63-74
Citations number
36
Categorie Soggetti
Physics, Condensed Matter","Chemistry Physical
Journal title
Solid state ionics → ACNP
ISSN journal
01672738
Volume
97
Issue
1-4
Year of publication
1997
Pages
63 - 74
Database
ISI
SICI code
0167-2738(1997)97:1-4<63:EIAIIN>2.0.ZU;2-R
Abstract
This paper reviews the main theoretical approaches proposed to underst and ion permeation in gramicidin, a model for more complex biological ion channels. Continuum and molecular dynamics viewpoints have contrib uted to significant insights in the essential transport mechanisms. Th e focus is on the recent semi-microscopic approach which analyzes the microscopic single file aspects of the system without neglecting the l ong range macroscopic effect of both solvent and membrane.