Prolyl endopeptidase inhibitors

Authors
Hermecz, I Kanai, K
Citation
I. Hermecz et K. Kanai, Prolyl endopeptidase inhibitors, FARMACO, 55(3), 2000, pp. 188-190
Citations number
2
Categorie Soggetti
Pharmacology & Toxicology
Journal title
FARMACO
ISSN journal
0014827X → ACNP
Volume
55
Issue
3
Year of publication
2000
Pages
188 - 190
Database
ISI
SICI code
0014-827X(200003)55:3<188:PEI>2.0.ZU;2-E
Abstract
Selective prolyl endopeptidase inhibitors were elaborated by modification o f the structure of SUAM-1221, by using a CoMFA study and protein crystallog raphy. The most active representatives of omega-(N-hetaryl)alkanoylprolylpy rrolidines, containing 2- or 3-methylene chain links have high activity (IC 50 10(-9) similar to 10(-11))and exhibit significant in vivo activities. (C ) 2000 Elsevier Science S.A. All rights reserved.