Novel approaches in the rational design of antifungal agents of low toxicity

This paper presents an overview of studies on novel strategies for the rati onal design of antifungal agents of low toxicity and overcoming the multidr ug resistance (MDR) of fungi. This goal was achieved both due to the introd uction of a novel target, glucosamine-6-phosphate synthase, as well as to t he recognition of molecular basis of selectivity of action of amphotericin B derivatives. (C) 2000 Published by Elsevier Science S.A. All rights reser ved.