4-dialkylamino-1-(5-substituted or unsubstituted 1-phenyl-1H-pyrazol-4-yl)butan-1-ols: synthesis and evaluation of analgesic, anti-inflammatory and platelet anti-aggregating activities

Authors
Menozzi, G Mosti, L Merello, L Piana, A Armani, U Ghia, M Angiola, M Mattioli, F
Citation
G. Menozzi et al., 4-dialkylamino-1-(5-substituted or unsubstituted 1-phenyl-1H-pyrazol-4-yl)butan-1-ols: synthesis and evaluation of analgesic, anti-inflammatory and platelet anti-aggregating activities, FARMACO, 55(3), 2000, pp. 219-226
Citations number
15
Categorie Soggetti
Pharmacology & Toxicology
Journal title
FARMACO
ISSN journal
0014827X → ACNP
Volume
55
Issue
3
Year of publication
2000
Pages
219 - 226
Database
ISI
SICI code
0014-827X(200003)55:3<219:4OU1>2.0.ZU;2-0
Abstract
A number of 4-dialkylamino-1-(5-substituted or unsubstituted 1-phenyl-1H-py razol-4-yl)butan-1-ols 2a-n were synthesized and tested in vivo for anti-in flammatory and analgesic activities and in vitro for platelet anti-aggregat ing activity. Dimethyl-aminoderivatives 2b, e, g showed good analgesic acti vity; almost all of them had strong platelet anti-aggregating properties at a final concentration of 1 x 10(-3) M; pyrazoles 2c, d, f-h showed weak an ti-inflammatory activity. (C) 2000 Elsevier Science S.A. All rights reserve d.