Genetic structure of native Andean populations from Argentina inhabiting different altitudes

Citation
Da. Demarchi et al., Genetic structure of native Andean populations from Argentina inhabiting different altitudes, HUMAN BIOL, 72(3), 2000, pp. 519-525
Citations number
18
Categorie Soggetti
Medical Research General Topics
Journal title
HUMAN BIOLOGY
ISSN journal
00187143 → ACNP
Volume
72
Issue
3
Year of publication
2000
Pages
519 - 525
Database
ISI
SICI code
0018-7143(200006)72:3<519:GSONAP>2.0.ZU;2-W
Abstract
On the basis of erythrocyte and serum protein polymorphisms, we investigate d the level of genetic differentiation among 3 Argentinian native populatio ns sharing ethnic and morphological characteristics but inhabiting differen t altitudes in the Andes. Of the 15 loci studied, 8 are monomorphic. Phenot ype distribution of the polymorphic systems are in agreement with Hardy-Wei nberg equilibrium, except for malic enzyme (MOD), where a silent allele was found. The 2 highland populations exhibit a close genetic similarity, prob ably as a result of intense gene flow, The lowland population shows reduced genetic diversity, which suggests the influence of stochastic phenomena su ch as the founder effect.