A systematic evaluation of molecular recognition phenomena. 1. Interactionbetween phosphates and nucleotides with hexaazamacrocyclic ligands containing m-xylylic spacers
C. Anda et al., A systematic evaluation of molecular recognition phenomena. 1. Interactionbetween phosphates and nucleotides with hexaazamacrocyclic ligands containing m-xylylic spacers, INORG CHEM, 39(14), 2000, pp. 2986-2999
The host-guest interactions between ortho- (Ph), pyro- (Pp), and tripolypho
sphate (Tr) anions together with ATP (At), ADP (Ad), and AMP (Am) nucleotid
es and the hexaazamacrocyclic ligand 3,7,11,19,23,27-hexaazatricyclo[27.3.1
.1 (13,17)]triaconta-1(32),13, 15, 17(34),29(33),30-hexaene (Bn) have been
investigated by potentiometric equilibrium methods. Ternary complexes are f
ormed in aqueous solution as a result of hydrogen bond formation and Coulom
bic attraction between the host and the guest. Formation constants for all
the species obtained are reported. The selectivity of the Bn ligand with re
gard to the phosphate and nucleotide substrates is discussed and illustrate
d with species distribution diagrams. A comparison of the present results w
ith those obtained for the similar but smaller macrocyclic ligand 3,6,9,17,
20,23-hexaazatricyclo[23.3.3.1.1(11,15)]triaconta- 1(29),11(30),12,14,25,27
-hexaene (Bd) is also discussed. It is found that the competition of the Ed
and Bn ligands for the formation of ternary species with a specific substr
ate is strongly dependent on the p[H]. The crystal structure of the compoun
d [(H6Bn)(H2PO4)(6)]. 2H(2)O with empirical formula C28H68N6O26P6 has been
solved by means of X-ray diffraction analysis. The compound belongs to the
triclinic P (1) over bar space group with Z = 1, a = 8.892(2) Angstrom, b =
9.369(4) Angstrom, c = 16.337(8) Angstrom, alpha = 73.72(4)degrees, beta =
83.01(4)degrees, and gamma = 64.81.(3)degrees. The phosphate counterions a
re found to bridge adjacent layers of macrocyclic molecules through an exte
nsive hydrogen-bonding network.