Objective. To describe the design and implementation of "INFUSION TOOLBOX,"
a software tool to control and monitor multiple intravenous drug infusions
simultaneously using pharmacokinetic and pharmacodynamic principles. Metho
ds. INFUSION TOOLBOX has been designed to present a graphical interface. Ob
ject Oriented design was used and the software was implemented using Smallt
alk, to run on a PC. Basic tools are available to manage patient, drugs, pu
mps and reports. These tools are the PatientPanel, the DrugPanel, the PumpP
anel and the HistoryPanel. The screen is built dynamically. The panels may
be collapsed or closed to avoid a crowded display. We also built control pa
nels such as the Target ControlPanel which calculates the best infusion seq
uence to bring the drug concentration in the plasma compartment to a preset
value. Before drug delivery, the user enters the patient's data, selects a
drug, enters its dilution factor and chooses a pharmacokinetic model. The
calculated plasma concentration is continually displayed and updated. The a
nesthetist may ask for the history of the delivery to obtain a graphic repo
rt or to add events to the logbook. A panel targeting the effect is used wh
en a pharmacodynamic model is known. Data files for drugs, pumps and surger
y are upgradable. Discussion. By creating a resizeable ControlPanelwe enabl
e the anesthetist to display the information he wishes, when he wishes it.
The available panels are diverse enough to meet the anesthetist needs; they
may be adapted to the drug used, pumps used and surgery. It is the anesthe
tist who builds dynamically its different control screens. Conclusion. By a
dopting an evolutionary solution model we have achieved considerable succes
s in building our drug delivery monitor. In addition we have gained valuabl
e insight into the anesthesia information domain that will allow us to furt
her enhance and expand the system.