Combinatorial synthesis of heterocycles: Solid-phase synthesis of 2-amino-4(1H)-quinazolinone derivatives

Authors
Gopalsamy, A Yang, H
Citation
A. Gopalsamy et H. Yang, Combinatorial synthesis of heterocycles: Solid-phase synthesis of 2-amino-4(1H)-quinazolinone derivatives, J COMB CHEM, 2(4), 2000, pp. 378-381
Citations number
27
Categorie Soggetti
Chemistry & Analysis",Chemistry
Journal title
JOURNAL OF COMBINATORIAL CHEMISTRY
ISSN journal
15204766 → ACNP
Volume
2
Issue
4
Year of publication
2000
Pages
378 - 381
Database
ISI
SICI code
1520-4766(200007/08)2:4<378:CSOHSS>2.0.ZU;2-P
Abstract
A new solid-phase synthesis of various substituted 2-amino-4(1H)-quinazolin ones from a resin bound amine component is described. The amine was readily converted to the corresponding polymer bound S-methylthiopseudourea. Conde nsation with different substituted isatoic anhydrides afforded 2-amino-4(1H )-quinazolinone derivatives. The method is amenable for combinatorial libra ry generation.