A. Gopalsamy et H. Yang, Combinatorial synthesis of heterocycles: Solid-phase synthesis of 2-amino-4(1H)-quinazolinone derivatives, J COMB CHEM, 2(4), 2000, pp. 378-381
A new solid-phase synthesis of various substituted 2-amino-4(1H)-quinazolin
ones from a resin bound amine component is described. The amine was readily
converted to the corresponding polymer bound S-methylthiopseudourea. Conde
nsation with different substituted isatoic anhydrides afforded 2-amino-4(1H
)-quinazolinone derivatives. The method is amenable for combinatorial libra
ry generation.