Ik. Campbell et al., The colony-stimulating factors and collagen-induced arthritis: exacerbation of disease by M-CSF and G-CSF and requirement for endogenous M-CSF, J LEUK BIOL, 68(1), 2000, pp. 144-150
There is increasing evidence that the colony-stimulating factors (CSFs) may
play a part in chronic inflammatory autoimmune diseases, such as rheumatoi
d arthritis (RA). We examined the involvement of macrophage CSF (M-CSF or C
SF-1) and granulocyte CSF (G-CSF) in collagen-induced arthritis (CIA), a mu
rine model of EW, Daily injections of M-CSF or G-CSF, 20-24 days postprimar
y immunization with type II collagen, exacerbated disease symptoms in subop
timally immunized DBA/1 mice. Support for the involvement of endogenous M-C
SF in CIA was obtained by studies in which neutralizing monoclonal antibody
reduced the severity of established CIA and also by studies showing the re
sistance of M-CSF-deficient op/op mice to CIA induction, These studies show
that M-CSF and G-CSF can be proinflammatory in CIA and provide evidence th
at macroghage- and granulocyte-lineage tells can exacerbate CIA. Our result
s also show that M-CSF-dependent cells are essential for CIA development, s
uggesting M-CSF may be a suitable target for therapeutic intervention in RA
.