Newborn screening for haemoglobinopathies: the Brussels experience

Objectives-To determine the prevalence of haemoglobinopathies and the need for neonatal screening for haemoglobinopathies in Brussels. Methods-Between December 1994 and June 1998 23136 cord blood samples obtain ed in eight hospital nurseries of Brussels were systematically screened for haemoglobinopathies by isoelectric focusing. Results-45% of the newborns were from regions at risk for haemoglobinopathi es. Sickle cell disease was diagnosed for 11 neonates (0.048%) and beta tha lassaemia major for one neonate. Three hundred and fifty neonates (1.5%) we re carriers for a haemoglobin variant, and Hb Bart's was found in 672 cases (2.9%). These prevalences are similar to those reported elsewhere in north ern Europe. Conclusions-These results confirm the value of universal screening for haem oglobinopathies in Brussels.