What can we do to improve physical function in older persons with type 2 diabetes?

Background. Older persons with type 2 diabetes are at higher risk for funct ional impairment than are their age-matched counterparts without diabetes. We therefore sought to identify factors associated with impaired physical f unction in older persons with type 2 diabetes by using a cross-sectional st udy design. Methods. We studied 1238 persons with type 2 diabetes who were 55 years of age or older and enrolled in die Type II Diabetes Patient Outcomes Research Team (PORT) project. Subjects were primary care patients at a large staff model health maintenance organization who had completed a mailed survey tha t collected information about demographics (age, race, marital status, inco me, education, gender, and body mass index [BMI]), health behaviors (exerci se, smoking, and alcohol), care and control of diabetes (therapy, self-repo rted glucose control, home glucose monitoring. and disease duration), mood (Center for Epidemiologic Studies-Depression Scale ICES-DI), comorbidity, a nd the Short-Form-36 health survey (SF-36). We evaluated the bivariate relationships between the PFI-10 a 10-item measu re of physical function from the SP-36, and candidate independent variables from the domains described previously. Variables that were significant at an a level of .10 were entered into a multiple linear regression model. Results. There were eight independent predictors of impaired physical funct ion (all p < .05, R-2 = .40). Factors associated with impaired function in order of their relative importance were as follows: a higher comorbidity sc ore, older age, obesity, lack of regular exercise, CES-D score higher than 20, taking insulin, lower formal education, and abstinence from alcohol. Conclusions. Increased comorbidity and older age are associated with poorer function, as is the severity of diabetes and less formal education. Exerci se, lower BMI, and better mood are associated with better function. Therefo re, promoting regular exercise and weight loss, in addition to treating dep ression, are likely to preserve or even improve the functional status of ol der persons with type 2 diabetes. Moderate alcohol use may be beneficial as well. The extent to which these relationships persist in prospective studi es or clinical trials remains to be evaluated.