Mi. Miranda et al., RECOVERY OF TASTE-AVERSION LEARNING INDUCED BY FETAL NEOCORTEX GRAFTS- CORRELATION WITH IN-VIVO EXTRACELLULAR ACETYLCHOLINE, Brain research, 759(1), 1997, pp. 141-148
Rats showing disrupted taste aversion due to insular cortex lesions, r
eceived either homotopic or heterotopic (occipital) cortical fetal bra
in grafts. Behavioral results showed that the recovery of the ability
to acquire conditioned taste aversions induced by fetal grafts depende
d on post-graft time (45 but not at 15 days) and tissue specificity (h
omotopic but not heterotopic). In vivo analysis of acetylcholine (ACh)
release revealed that only the group receiving homotopic grafts and t
ested 45 days post graft had a release of ACh after KCI stimulation si
milar to that in the control group. Furthermore, homotopic grafts and
lesioned groups showed significantly weaker specific receptor binding
of [H-3]L-glutamate compared with controls. These results suggest that
ACh is specifically involved in the process of behavioral recovery in
duced by homotopic cortical transplants.